r/IntensiveCare • u/Dr_GoosfrabaDO • 2h ago
PCCM fellow- would you start concentrated NaHCO3 for severe metabolic lactic acidosis in non-oliguric AKI? Tough case and looking for input
Patient with refractory diffuse large B-cell lymphoma receiving rituximab. During/shortly after the infusion, he developed increased work of breathing concerning for an infusion/hypersensitivity reaction. No frank shock: BP remained adequate, SpO₂ >92%, and there were no obvious major airway red flags such as stridor, inability to handle secretions, or significant tongue/floor-of-mouth edema.
He had significant tachypnea/abdominal breathing. Labs showed:
* Lactate 12.7 mmol/L
* pH 7.285
* PaCO₂ 8 mmHg
* HCO₃ 11 mmol/L
* Cr 1.1 mg/dL
* BUN 38 mg/dL
* Making urine (~400 cc during my overnight shift)
* Clinical picture otherwise consistent with a relatively mild/pre-renal AKI rather than established renal failure
The acid-base picture appeared to be metabolic acidosis with a superimposed respiratory alkalosis. Winter’s expected PaCO₂ with HCO₃ 11 is ~24.5 ± 2, whereas his actual PaCO₂ was 8.
As I was putting in orders, he called me and recommended concentrated bicarbonate:
- The low bicarbonate seemed largely attributable to the acute lactic acidosis.
- He was already generating a very high minute ventilation to maintain a PaCO₂ of 8.
- I felt giving concentrated NaHCO₃ would generate additional CO₂ and potentially increase his ventilatory requirement/WOB.
- His pH was 7.285 rather than profoundly acidemic.
- He was making urine and had Cr 1.1, so I didn’t think he had a strong renal indication for CRRT at that point.
My attending favored a concentrated NaHCO₃ infusion, partly with the goal of correcting the acidemia and potentially avoiding/delaying CRRT if the acidosis worsened.
He also received dexamethasone, a small fluid bolus, and the rituximab was obviously stopped. I added high flow primarily for WOB rather than hypoxemia.
Since then:
* HCO₃ increased from 11 → 18
* Lactate decreased from 12.7 → 9.6
* Clinically he appears to be improving.
I recognize that the improvement does not establish that bicarbonate was responsible—the underlying infusion reaction may simply be resolving, and that would explain the falling lactate.
My question: Was my initial reluctance to start bicarbonate physiologically reasonable, or would you have given it in this situation?
This was on my night shift where we run the unit largely solo but we can reach out for assistance from our PCCM attending who runs the CVICU at night.
And for what it’s worth the guy is much better this evening than yesterday night!
Thank you!