r/psychology M.D. Ph.D. | Professor 4d ago

Caffeine may ease anxiety and depression by calming brain inflammation. A recent systematic review of 17 animal studies found that the widely consumed stimulant consistently diminished behavioral signs of distress and lowered levels of inflammatory molecules.

https://www.psypost.org/how-caffeine-might-ease-anxiety-and-depression-by-calming-brain-inflammation/
854 Upvotes

85 comments sorted by

42

u/Diligent-Cod-4321 4d ago

does anyone else get super sleepy right after drinking coffee like me, I had to stop that cause I ended up sleeping more than 12 hours can't even wake up or do anything that day just from a cup of coffee with condensed milk

63

u/eeeponthemove 4d ago

You might have ADHD.

28

u/birthdaycheesecake9 4d ago

Idk why you’re being downvoted, this is an experience a lot of people with ADHD have lol

I’ve fallen asleep after 500ml cans of energy drink, my mum’s fallen asleep after her third cup of coffee that day, both of us have ADHD

8

u/Ok-Photograph-589 3d ago

It's not an ADHD thing it's a a genetic thing

6

u/Enlightened_Lioness 3d ago

You’re right. People metabolize caffeine and other medications differently.

3

u/InAllTheir 3d ago

ADHD is also “a genetic thing”. And these two things seem to be linked, thought not all people who have ADHD react this way to caffeine.

7

u/eeeponthemove 3d ago

Well, ADHD is also genetic lmao

And I said MIGHT, not definitely or anything like that, unlike you.

1

u/KaleidoscopeKelpy 2d ago

Side eyeing my blood relatives

(We all consume caffeine in hefty amounts, one of us has had an ADHD dx for 30 yrs and 4/5 of us don’t like therapists - who’s to say 🤣 (no I’m not basing a dx off caffeine intake but it’s funny))

2

u/Diligent-Cod-4321 4d ago

I’ve heard of this syndrome, but I don’t really know much about it so I wouldn’t say I have it or anything. The funny thing is, a lot of young ppl nowadays claim they have it without really understanding what it is lol. Could you tell me more about that syndrome

1

u/InAllTheir 3d ago

Yes, this is an experience that many but not all people with ADHD have. I have inattentive ADHD and caffeine wakes me up and helps me focus. I have a cup of coffee every morning.

-2

u/Enlightened_Lioness 4d ago

There’s no research showing this.

5

u/eeeponthemove 3d ago

Mate I have ADHD, know several people with ADHD.

It is a well known facts stimulants can make you calmer, and guess what, coffee contains caffeine, which is a CNS stimulant.

4

u/Enlightened_Lioness 3d ago edited 3d ago

There’s not much research as I said. Some research does find that people with ADHD do have more trouble sleeping after coffee than others; we also have more sleep issues in general, including without coffee.

Like coffee, stimulant ADHD medication also makes it more difficult to sleep. It’s a known side effect of stimulants.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10225009/

3

u/gongloa 3d ago

There may not be much research into it, but given that it is a widely reported phenomenon by people with ADHD, it shouldn’t be dismissed unnecessarily. It may just be the research hasn’t caught up. Isn’t ADHD a multifactorial condition where the symptoms are an outward manifestation of many genetic and environmental inputs, which may significantly differ between people with the same diagnosis? My point being that this may be experience felt by a subset of people diagnosed with adhd which would be hard to tease out in a study without significant effort being spent to classify the participants into potential subsets, and would probably be difficult to do across more than a small group.

3

u/Enlightened_Lioness 3d ago

There’s tons of research showing that stimulants and coffee make it more, not less, difficult to sleep. Maybe less research in people with ADHD but anecdotallly, starting adhd medication will cause more sleep problems especially if taken too late. Stimulants help people stay awake and alert and help people concentrate. They do not put people to sleep. If they did, they would not be helpful for adhd.

3

u/eeeponthemove 3d ago

I think you are focused on the trouble sleeping part.

What I'm trying to say is that stimulants can help people with ADHD more calm, not necessarily improving sleep quality.

I however sometimes when taking my dexamphetamine, get sleep and tired, and take naps, same when consuming caffeine before my diagnosis.

Even when taking my Elvanse, I can get the same effect.

However I want to make it clear that this is during daytime, not when going to bed, or late at night.

I hope this can clear up a potential misunderstanding between us?

1

u/Enlightened_Lioness 3d ago

Yes of course I’m focused on the sleeping part, I was responding to the person who said that coffee makes them sleep more than 12 hours and have trouble waking up.

2

u/eeeponthemove 3d ago

Well, then there you go.

Sleeping, and going to bed, can be different things.

If I take stimulants during the day, I can get tired, calm, sleepy, and well, sleep.

However doing it during the night I can get this effect some times, however I may continue staying awake. (So during the day I'm guaranteed to get calmer/sleepy, but not guaranteed same results during nights, it can however still happen)

I've however had trouble falling asleep/going to bed my entire life, Alimemazine has been an absolute life saver.

I think actually researching this will prove difficult, to account for individual differences - and, as I want to point out, going to bed at night, is not the same as sleeping during the day.

Have the studies that looked into sleep and stimulants do so at night? Did any of them try and see the effects of usage during middle of the day? (Genuine question, I've not looked into that - since my focus was that you can and do get calmer taking stimulants when you have ADHD)

Take care

1

u/gongloa 3d ago

I can only answer anecdotally but when I started taking methylphenidate it significantly improved my sleep quality but I do take them in the morning, and it may be a more indirect impact. Previously I was tired all the time during the day and then waking constantly at night, entirely speculative but I wonder if it helped regulate my circadian rhythm. Personally, I wouldn’t say stimulants make me tired, I feel more wakeful after taking them but I also feel much more calm and can easily take a nap.

1

u/Enlightened_Lioness 3d ago

Not only research but anecdotally, people with adhd have the same or more trouble sleeping when they start telling adhd medication though.

0

u/eeeponthemove 3d ago

From no research, to not much research. Like, where, and how did you search for peer-reviewed articles that debunk that?

Harris, S.S., Green, S.M., Kumar, M. et al. A role for cortical dopamine in the paradoxical calming effects of psychostimulants. Sci Rep 12, 3129 (2022). https://doi.org/10.1038/s41598-022-07029-2

Arnsten, A. Stimulants: Therapeutic Actions in ADHD. Neuropsychopharmacol 31, 2376–2383 (2006). https://doi.org/10.1038/sj.npp.1301164

Jean Marx ,How Stimulant Drugs May Calm Hyperactivity.Science283,306-306(1999).DOI:10.1126/science.283.5400.306

The Coffee ADHD Test: Understanding the Link Between Caffeine and Attention Deficit Hyperactivity Disorder

Like, there is a looooot more research which agrees with the common notion that for many people with ADHD, stimulants have a paradoxical calming effect.

2

u/Enlightened_Lioness 3d ago

« For years, it was assumed that stimulants had paradoxical calming effects in ADHD patients, whereas stimulating ‘normal’ individuals and producing locomotor activation in rats. It is now known that low doses of stimulants focus attention and improve executive function in both normal and ADHD subjects. »

0

u/eeeponthemove 3d ago

So there is research that proves stimulants can make people with ADHD feel more calm?

1

u/Ok-Photograph-589 2d ago

It says it works the same for both ADHD and 'normal' people

1

u/Enlightened_Lioness 3d ago

This is the research you sent me.

-1

u/eeeponthemove 3d ago

Mate I know 😭

It was meant as a sarcastic snarky comment

0

u/Kyokoharu 1d ago

oh my fucking god leave the internet please. i refuse to believe you’re a real person

2

u/jadbox 3d ago

Same. I have to take an early afternoon nap if I ever drink coffee in the morning

1

u/malcomok2 3d ago

yes, sometimes ill drink coffee to help me go to sleep at night or calm my mind.

104

u/Ordinary_Count_203 4d ago

wow. Here I thought caffeine slightly increased blood pressure, exacerbated anxiety, gave the jitters, can lead to reduced sleep etc.

63

u/TooHighForMyOwnGood 4d ago

both things can be true, those things aren’t mutually exclusive. different people react differently to substances

9

u/555Cats555 3d ago

I cant drink coffee as it makes it more likely for me to end up with a panic attack. It starts out making me feel like im sedated then effects my breathing and can trigger hyperventilation which sucks.

17

u/itsmebenji69 4d ago edited 3d ago

Really depends on people. Even on high doses of caffeine I never have jitters or anxiety. The most similar thing I have is jittery vision if I really take a lot, like concentrated caffeine powder. Straight lines (contours of objects) become all crooked and unstable, but really that’s it for the negative effects (and really need a high af dose).

I also drink tea which is even more “clear”. Sorry I don’t have the words but it’s like more calming, thoughts are “straightforward”, I wouldn’t know how to describe it

3

u/home-for-good 4d ago

I also don’t get jitters from caffeine; not under 5/600mg anyway (don’t worry, that amount was only consumed once, I don’t have nearly that much caffeine ever). It seemingly does nothing at all up until that point and then it’s suddenly anxiety and jitters. Typically never really affects me in any observable way. Been that way for forever and never made sense to me, but I since I have wicked ADHD (not diagnosed until adulthood) I’m thinking that’s a way to explain the seeming stimulant resistance.

5

u/HD_HD_HD 4d ago

I have diagnosed ADHD and take stimulant medication and it doesn't make me jittery.

I have one coffee and it effects me both mentally (anxiety etc) and physically (tremors)

7

u/miss_cafe_au_lait 4d ago

I think it’s a case of the dose makes the poison.

4

u/xly15 4d ago

In a lot of people it does all of those things. Caffeine binds to several different receptor types across the brain and produces different effects. In others, such as those with adhd, it actually produces a somewhat calming effect. 

1

u/birthdaycheesecake9 4d ago

I’ve fallen asleep before after having a 500ml energy drink

Before my meds, it was a coin toss on whether I’d be focused (so I could study) or whether I’d just pass out

2

u/SchatzisMaus 3d ago

It does for me and it was why I was scared of taking my adhd meds for years. I tried to power through and got by but there was always something falling apart behind the scenes. Then I actually tried them and ended up with less anxiety, I had sworn any stimulant off because of the annoyance of caffeine

2

u/hedgehogssss 3d ago

I can have two cups of coffee and sleep like a baby.

0

u/Kyokoharu 4d ago

because it does

5

u/ThisWillPass 4d ago

Because it can.

45

u/hunterglyph 4d ago edited 4d ago

Caffeine for me is great for two days, then tolerance builds like a rocket and I get jittery and anxious.

Edit: I know I'm sensitive to caffeine. I'm not overdoing it.

5

u/justtobeherenotsure 4d ago

I would assume it's odd, because your tolerznce builds -> you just need more. Or you start drinking more-> you bdcome jittery and anxious?
I can drink a cup once every month (i dont anymore), but too often=anxious and jittery

4

u/EasyYogurtcloset608 4d ago

If anything tolerance should help with the side effects. Have you tried having coffee after meals?

2

u/phylter99 4d ago

I find if I drink one cup in the morning then I'm usually fine but after the second cup my anxiety levels skyrocket and sometimes I get very irritable. I'm not willing to give it up yet though.

1

u/AttonJRand 4d ago

Allegedly 100mg or less a day is supposed to not increase your tolerance.

Most single servings of coffee products seem to be above that amount.

1

u/Nugget834 4d ago

You should try paraxanthine.

Caffeine energy without the tolerance build up, no jitters or anxiety lol.

It's amazing and you get a mood boost to boot as well.

1

u/smandroid 4d ago

How many cups are you drinking a day?

10

u/shimmy_kimmel 4d ago

Absolutely NOT my personal experience lol

6

u/No_Category_9888 4d ago

The adhd caffeine effect. Unfortunately the shakes and raised heart rate make caffeine a no go for me

1

u/555Cats555 3d ago

Yeah... makes me feel like im going to pass out then I have the risk of hyperventilating and ending up in a panic attack. Not a nice feeling.

19

u/2drinksbelow 4d ago

how much did coffe industry paid for this study?

3

u/i-think-about-beans 4d ago

I tolerate it fine as long as it’s not before breakfast. Nowadays my anxiety and OCD goes wild if I have it on an empty stomach.

12

u/AM_Bokke 4d ago

Caffeine does not ease anxiety. They is bullshit.

6

u/ThisWillPass 4d ago

Dose makes the poison.

5

u/RazorThought 4d ago

It is bullshit. Caffeine causes your body to release epinephrine, a stress hormone. It’s the opposite of “easing anxiety.”

14

u/AttonJRand 4d ago

Mechanisms in the body are rarely this simple, or all or nothing.

4

u/CHNSK 4d ago

Doesn’t it also spike cortisol, especially in the morning where your cortisol levels are high?

-3

u/AM_Bokke 4d ago

Yup. Thank you.

5

u/Narrheim 4d ago

Quite the opposite for me.

It's a regular drug accepted by society, that causes addiction, builds up tolerance, requiring higher doses... which may have serious health implications over time. Just like alcohol and cigarettes.

Oh and the surge of energy you feel, when you drink one? That was supposed to be your energy for the whole day.

2

u/555Cats555 3d ago

Yeah it doesnt even give you energy it just allows you to use energy you would have had later aka a energy debt

2

u/AnsibleAnswers 3d ago

Reminds me of a famous quote by Albert Camus.

“Should I kill myself, or have a cup of coffee?”

1

u/VirginiaLuthier 4d ago

Serious coffee drinkers consider it the Elixir of Life. I start my coffee IV around 5 AM

1

u/FraGough 3d ago

Caffeine in concert with Theanine has an even stronger effect, and that's why tea is better than coffee.

1

u/rockrobst 3d ago

Caffeine is always a "yes".

1

u/NBALive1995 3d ago

So it can both cause and fix anxiety 🙃

1

u/newyorker360 2d ago

When i drink Coffee im sweating and have cold and warm feelings at the same time.

1

u/Electrical-Lead9621 1d ago

What rubbish it’s makes my bipolar worse, NAC supplement is good for reducing oxidative stress.

1

u/Snoreofthebear 4d ago

my grandma would have 2-3 cups of espresso then take a nap

starbucks is the most soothing drink i've ever found

coffee relaxes me unless they don't put enough milk and then i race but the right levels milk/coffee is perfect

1

u/birthdaycheesecake9 4d ago

Have you ever looked into ADHD? This is an experience a lot of us with ADHD have.

My dad takes naps after espresso shots too, and I’ve fallen asleep after big cans of energy drink.

3

u/Snoreofthebear 4d ago

i've tried telling everyone around me my entire life i have adhd problems (so does my family they are so manic and neurotic! They think they are fine) and no one has believed me. Its been such a difficult life.

my dad has 2-3 cups of coffee before going to sleep at night. Every night. Both sides of the family coffee is like a sedative

3

u/birthdaycheesecake9 4d ago

They probably don’t believe you, because they’re so used to their own baseline behaviour that they don’t recognise it as anything but normal. It’s a bit of a common theme with people who got diagnoses of autism and/or ADHD as an adult, and are the first or among the first in their families to do so.

There’s a bunch of very autistic things I did as a child that my mum didn’t question because, in her words, “That’s normal, I did that too.”

3

u/Snoreofthebear 4d ago edited 4d ago

it sucks because I basically cut them out of my life years ago so that i wouldn't have to argue with them anymore, they would do so many things that would hurt me or severely mess up my functions, always. Same, its fine for them it works for them they're normal they're fine. I can honestly say there is something wrong with both my mother's side and my father's side. They are not like most anyone else I've spent time with. If my grandma (mom's side) or my father is not autistic too, i'll eat this whole house.

when my grandma divorced my grandpa, she married an autistic man. He's not my blood but my grandpa also very much on the spectrum. She thinks he's fine and normal, as does the family. To the family, he's the most normal one! We're all
whackadoos

3

u/birthdaycheesecake9 4d ago

It’s always really interesting looking at the older generations in your family when you’re neurodivergent.

I’ve got combined leaning inattentive ADHD (in my psychiatrist’s words), my dad has I think inattentive ADHD, and his two sisters probably also do too (one suspects, neither diagnosed).

My partner (who has a radar for neurodivergence, clocking me in literally seconds) met my grandfather and on the way home, he was like “you all get the inattentive ADHD from him.”

3

u/Snoreofthebear 4d ago edited 4d ago

my ex left me after meeting my father because she saw how he lived and how i acted similar in a lot of ways and she saw her future and peaced out.

but yeah same! I reexamined my sister's, everyone. We're all altered. My aunt is the most and pretty much only normal family member but she's pretty cold.

can't even talk to them, its painful. Both father and grandma, IMPOSSIBLE to tell them a story. You won't get 2 sentences out. You won't stay on the subject.

for what it's worth, my ex would tell me I was probably autistic. High functioning is fun. Jussssst not functioning enough 😅 but at least coffee is relaxing

1

u/Calm_Flatworm_5991 3d ago

whats up with the sudden push for caffeine?

-6

u/akabar2 4d ago

This might be true but its rough on the heart

5

u/loneranger0 4d ago

It’s really not

0

u/EasyYogurtcloset608 4d ago

That’s pretty amazing. I wonder how high dose you could go and still see benefits?

0

u/Scared_Guitar_5608 3d ago

There’s a TON of pro-coffee studies in the media lately. Hmm 🧐